How Palmitoylethanolamide Works
The benefits of Palmitoylethanolamide.
PEA has piqued the interest of scientists since its discovery in the 1950s. Although large-scale safety and effectiveness studies are only recently starting to emerge, Despite this, PEA shows big potential as a pain reliever and anti-inflammatory.
A growing number of chronic disease sufferers who consume PEA believe it helps them deal with chronic and neuropathic pain.
The science behind PEA.
Scientists are currently researching the effects of PEA on cannabinoid receptor activation. Preliminary studies show PEA may benefit brain, heart, and immunological function.
PEA is a fatty acid that is similar to anandamide, the body’s major cannabinoid joy molecule.
Unlike ordinary fats, amide-containing fatty acids such as PEA and cannabinoids have a direct role in nerve signaling. These fascinating and recently discovered compounds are referred to as “neuroactive lipids.”
Why is PEA important?
One of the main problems with prescription drugs is that they can be addictive and cause a variety of side effects. Palmitoylethanolamide, on the other hand, is a natural substance that has pain-relieving benefits without the risk of addiction or side effects.
PEA also helps reduce inflammation, which is often the root cause of pain.
Palmitoylethanolamide and inflammation
Palmitoylethanolamide (PEA) is a natural anti-inflammatory and pain reliever that has been shown to have similar effects as NSAIDs without the side effects or risks associated with these drugs. PEA works by activating nuclear peroxisome proliferator-activated receptors (PPARs), which regulate inflammation in cells throughout your body.
The activation of PPARs by PEA helps to reduce inflammation in the brain. This is important because chronic inflammation can lead to the development of neurodegenerative diseases like Alzheimer’s disease, Parkinson’s disease and multiple sclerosis. PEA also helps to protect neurons from damage and death, which can further reduce the risk of developing these diseases.
PEA stimulates the energy-boosting, fat-burning, anti-inflammatory PPAR alpha receptor. PEA also inhibits the activity of pro-inflammatory genes and the generation of several inflammatory chemicals by activating this important protein.
Evidence of PEA’s efficacy
PEA (600 mg PEA/day) decreased lower back pain in a trial of over 100 participants. It was so powerful that by the end of the experiment, half of the patients had stopped using any extra medicines.
Palmitoylethanolamide has been shown to improve inflammation and pain in arthritis. A study on inflammation and pain in arthritis showed that patients who took PEA had a significant reduction in pain, joint swelling, and morning stiffness.
Palmitoylethanolamide was also found to be safe and well tolerated in the study.
Synergistic effects when combined with other natural products
When combined with other natural antioxidant molecules like flavonoids, Polydatin, Luteolin, Quercetin, or Silyrmarin, PEA can effectively reduce inflammation.
This quality displays PEA’s ability to work both alone and in conjunction with other natural dietary compounds. Overall, these findings support the idea that PEA is a crucial endogenous inflammatory balancer.
In other words, PEA may be a viable option to anti-inflammatory medicines, or even a complementary therapy.
Research resources