How Palmitoylethanolamide Works

Overall Health

PEA plays a key role in maintaining homeostasis by regulating many physiological reactions associated with pain and inflammation. Some chronic conditions can deplete PEA, resulting in a hyper-immune response involving glial, microglial and mast cells.

Pain reduction

PEA occurs naturally in the body and in many foods. No side effects have been reported with its use, even at the highest doses. (Gabrielsson 2016)

In a recent meta-analysis of PEA involving a total of 1484 chronic pain patients, those taking PEA reported pain levels an average of 2.7 points lower than the control groups after 60 days

Brain Health

Excessive activation of these satellite, non-neuronal cells has been shown to maintain inflammation and result in neurodegeneration. PEA reduces excessive activation of these cells and decreases neuron loss

Purepea

What is Luteolin?

Luteolin is a potent bioflavonoid with antioxidant and anti-inflammatory properties. Like PEA, luteolin has several mechanisms of action. It inhibits mast cells, as well as mast cell-dependent T cell activation.* (Theoharides 2018) In addition, it modulates microglial activation and inhibits pro-inflammatory cytokine production. (Dirscherl 2010) It also acts on GABA and opioid receptors in the spinal cord.

SIDE EFFECT FREE!

PEA occurs naturally in the body and in many foods. No side effects have been reported with its use, even at the highest doses. (Gabrielsson 2016)
The recommended daily dose of Mirica is equivalent to the amount of luteolin found in one artichoke. At this dose luteolin is safe and no side effects have been reported.

Immune system boost

This combination has been shown to reduce pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6) and chemokines (MIP-1 alpha, MIP-2) significantly more than PEA or luteolin alone. Additionally, PEA with luteolin was shown to reduce oxidative and nitrosative damage more effectively than PEA or luteolin alone.